This mHealth Partnership seeks to support a scalable, cost-effective and sustainable national health information system in Tanzania. Making use of the rapidly increasing mobile network coverage in the country, the project aims to improve the information flow across and between different health system levels, reduce the response time for critical services and improve evidence-based planning and decision making. The programme facilitates the transmission via SMS of real-time notifications of infectious disease cases as well as broader disease trends (as part of the existing Integrated Disease Surveillance and Response (IDSR) strategy). This allows not only for a prompt automatic generation of SMS-alerts to district, regional and national public health officials, but also frees up precious time of health facility workers.